Discussion This study provides evidence that high-dose folic acid supplementation leads to genome-wide alterations in sperm DNA methylation, in particular, loss of methylation mostly in intergenic and low-density CpG regions. Analysis of the sperm DNA before and after high-dose folic acid supplementation showed that the methylation status of imprinted loci was within the normal range for all loci tested and was not altered in response to high-dose folic acid supplementation Fig. Men who had lower levels of folic acid in their diet had a higher rate of abnormal chromosomes in their sperm, according to a study by researchers at the University of California, Berkeley. However, data on some intergenic regions with low CpG-density and possible biological relevance may not be covered by RRBS. Before you start trying to conceive, he should make a list of all the medications he takes—including prescriptions, over-the-counter drugs, vitamins, and herbal supplements—and check them with his doctor. Folic acid, the synthetic form of folate, is used for the fortification of foods and in supplements.
To assess the global impact of high-dose folic acid on the sperm methylome, we used a next generation sequencing-based method, reduced representation bisulfite sequencing RRBS.
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She is also the creator of WhatToExpect. Published online Aug More in-depth studies are required to investigate whether alterations of folate and other metabolic pathways occur after high-dose folic acid supplementation in men. Click here to view. Folic Acid During Pregnancy. More on Trying to Conceive.