Folic acid and sperm

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Discussion This study provides evidence that high-dose folic acid supplementation leads to genome-wide alterations in sperm DNA methylation, in particular, loss of methylation mostly in intergenic and low-density CpG regions. Analysis of the sperm DNA before and after high-dose folic acid supplementation showed that the methylation status of imprinted loci was within the normal range for all loci tested and was not altered in response to high-dose folic acid supplementation Fig. Men who had lower levels of folic acid in their diet had a higher rate of abnormal chromosomes in their sperm, according to a study by researchers at the University of California, Berkeley. However, data on some intergenic regions with low CpG-density and possible biological relevance may not be covered by RRBS. Before you start trying to conceive, he should make a list of all the medications he takes—including prescriptions, over-the-counter drugs, vitamins, and herbal supplements—and check them with his doctor. Folic acid, the synthetic form of folate, is used for the fortification of foods and in supplements.

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To assess the global impact of high-dose folic acid on the sperm methylome, we used a next generation sequencing-based method, reduced representation bisulfite sequencing RRBS.

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She is also the creator of WhatToExpect. Published online Aug More in-depth studies are required to investigate whether alterations of folate and other metabolic pathways occur after high-dose folic acid supplementation in men. Click here to view. Folic Acid During Pregnancy. More on Trying to Conceive.

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